Endocrine Abstracts

Introduction: Hyponatraemia is a common biochemical abnormality in hospital patients, a robust management plan and correct diagnosis is important in the medical care of these patients. However these are frequently lacking.Methods: We audited the management and outcomes of hyponatraemia in a large district general hospital. In-patients for a period of 3 months starting from January 2004 with hyponatraemia (Sodium less than reference rang 132-146 mmol per ...

Adult survivors of haematological malignancies are subject to a number of putative insults to the skeleton. Adverse impacts on bone mass include sex-hormone deficiency, radiotherapy, chemotherapy, inadequate nutrition and a generalised catabolic state. We assessed BMD using DXA at the lumbar spine (LS) and femoral neck (FN) in 34 women with POF, defined by secondary amenorrhoea, elevated gonadotropins, and low oestradiol levels. Mean age at diagnosis was 29.7 (range 14–45...

The optimal oestrogen dose required to maintain bone mass in young women who develop POF is contentious. We reviewed longitudinal BMD data in 21 women with POF resulting from multi-modality cancer therapy for haematological malignancies. The 21 women were of mean age 30.6 (range 17–45) years at onset of amenorrhoea and weight 64.1+/−11.2 kg. Primary diagnoses were acute myeloid leukaemia (n=12), chronic myeloid leukaemia (n=5), acute lymphocytic leukae...